Epistasis and Entropy
نویسندگان
چکیده
منابع مشابه
Epistasis and Entropy
Epistasis is a key concept in the theory of adaptation. Indicators of epistasis are of interest for large systems where systematic fitness measurements may not be possible. Some recent approaches depend on information theory. We show that considering shared entropy for pairs of loci can be misleading. The reason is that shared entropy does not imply epistasis for the pair. This observation hold...
متن کاملNew Entropy-Based Measures of Gene Significance and Epistasis
A new framework to formulate and quantify the epistasis of a problem is proposed. It is based on Shannon’s information theory. With the framework, we suggest three epistasis-related measures: gene significance, gene epistasis, and problem epistasis. The measures are believed to be helpful to investigate both the individual epistasis of a gene group and the overall epistasis that a problem has. ...
متن کاملIdentification of epistasis in ischemic stroke using multifactor dimensionality reduction and entropy decomposition.
We investigated the genetic associations of ischemic stroke by identifying epistasis of its heterogeneous subtypes such as small vessel occlusion (SVO) and large artery atherosclerosis (LAA). Epistasis was analyzed with 24 genes in 207 controls and 271 patients (SVO = 110, LAA = 95) using multifactor dimensionality reduction and entropy decomposition. The multifactor dimensionality reduction an...
متن کاملEpistasis and Deceptivity
Deceptivity and epistasis both contribute to make fitness functions hard to optimize for a genetic algorithm. In this note we examine the relation between these concepts, with particular emphasis on their mutual reinforcement.
متن کاملEpigenetics, epistasis and epidemics
Department of Microbiology, Ramón y Cajal University Hospital, Ramón y Cajal Institute for Health Research (IRYCIS), Madrid, Spain *Correspondence address. Department of Microbiology, Ramón y Cajal University Hospital, Carretera de Colmenar km 9,100. 28034 Madrid, Spain. Tel:+34-913368832; Fax:+34-913368809; E-mail: [email protected] Received 27 March 2013; revised version accepted 5 April ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLOS Genetics
سال: 2016
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1006322